The Impact of Sodium Citrate, Phosphates, and Carnitine on Sports Performance: A Systematic Review


DOI:
https://doi.org/10.70736/2958.8332.kosalb.51Keywords:
Equivocal Supplements, Sodium Citrate, Phosphates, CarnitineAbstract
Study aim(s): The study aims to clarify the impact of sodium citrate, phosphates, and carnitine on sports performance through a systematic review of the literature. These supplements have not been extensively defined or tested in previous experimental studies. Therefore, this review seeks to provide clearer insights into their optimal dosage and timing of use, as existing research primarily focuses on dosage and usage protocols in experimental settings.
Methods: This study follows a systematic review model based on PRISMA standards. It aims to draw new conclusions regarding the Effects of Sodium Citrate, Phosphates, and Carnitine on Sports Performance and their potential impact on athletes’ health. The literature search was limited to studies published within the last five years.
Results: The findings indicate that sodium citrate may enhance athletic performance and support skill preservation, although it can cause temporary gastrointestinal discomfort. Phosphate supplementation shows potential benefits for endurance under hypoxic conditions but demonstrates inconsistent effects in trained athletes. Carnitine appears to be most effective for high-intensity performance, with both acute and chronic supplementation contributing to improved power output and overall health benefits.
Conclusions: While supplementation with sodium citrate, phosphate, and carnitine shows potential ergogenic benefits, their effectiveness depends on proper dosage and timing. Sodium citrate (0.5 g/kg BM) may enhance anaerobic performance but requires careful timing (200–240 min pre-exercise) to minimize gastrointestinal discomfort. The impact of sodium phosphate on aerobic performance varies among individuals, with responders particularly benefiting from supplementation, especially under hypoxic conditions. Carnitine supplementation appears most effective for high-intensity activities when taken chronically (2–2.72 g/day for 9–24 weeks) or acutely (3–4 g, 60–90 min pre-exercise).
References
Gruska N, Sarmento H, Martinho D, Field A, Massart A. Enhancing performance in young athletes: A systematic review of acute supplementation effects. Nutrients, 16(24), 4304; 2024, DOI: https://doi.org/10.3390/nu16244304.
Mielgo-Ayuso J, Pietrantonio L, Viribay A, Calleja-González J, González-Bernal J, Fernández-Lázaro D. Effect of acute and chronic oral L-carnitine supplementation on exercise performance based on the exercise intensity: A systematic review. Nutrients, 13(12), 4359; 2021, DOI: https://doi.org/10.3390/nu13124359.
World Anti-Doping Agency. (2023). 2024 Prohibited list. https://www.wada-ama.org/sites/default/files/2023zzzzzzzzzzzzzzzzzzazz-09/2024list_en_final_22_september_2023.pdf.
Requena B, Zabala M, Padial P, Feriche B. Sodium bicarbonate and sodium citrate: Ergogenic aids? Journal of Strength and Conditioning Research, 2005; 19(1), 213–224, DOI: https://doi.org/10.1519/13733.1.
McNaughton LR. (1990). Sodium citrate and anaerobic performance: Implications of dosage. European Journal of Applied Physiology and Occupational Physiology, 1990; 61(5–6), 392–397, DOI: https://doi.org/10.1007/BF00236058.
McNaughton L, Cedaro R. (1992). Sodium citrate ingestion and its effects on maximal anaerobic exercise of different durations. European Journal of Applied Physiology and Occupational Physiology, 1992; 64(1), 36–41, DOI: https://doi.org/10.3390/nu13124359.
Urwin CS, Dwyer DB, Carr AJ. Induced alkalosis and gastrointestinal symptoms after sodium citrate ingestion: A dose-response investigation. International Journal of Sport Nutrition and Exercise Metabolism, 2016; 26(6), 542–548, DOI: https://doi.org/10.1123/ijsnem.2015-0336.
Carr AJ, Hopkins WG, Gore CJ. Effects of acute alkalosis and acidosis on performance: A meta-analysis. Sports Medicine, 2011; 41(10), 801–814, DOI: https://doi.org/10.2165/11591440-000000000-00000.
Buck CL, Wallman KE, Dawson B, Guelfi KJ. Sodium phosphate as an ergogenic aid. Sports Medicine, 2013; 43(6), 425–435, DOI: https://doi.org/10.1007/s40279-013-0042-0.
Kreider RB. Phosphorous in exercise and sport. In J. A. Driskell & I. Wolinsky (Eds.), Macroelements, water and electrolytes in sport nutrition (pp. 29–43). CRC Press, 1999, DOI: https://doi.org/10.1201/9780203748527 5.
Kreider RB, Miller GW, Schenck D, Cortes CW, Miriel V, Somma CT, Hill D. Effects of phosphate loading on metabolic and myocardial responses to maximal and endurance exercise. International Journal of Sports Nutrition, 1992; 2(1), 20–47, DOI: https://doi.org/10.1123/ijsn.2.1.20.
Folland JP, Stern R, Brickley G. Sodium phosphate loading improves laboratory cycling time-trial performance in trained cyclists. Journal of Science and Medicine in Sport, 2008; 11(5), 464–468, DOI: https://doi.org/10.1016/j.jsams.2007.04.004.
Kopec BJ, Dawson BT, Buck C, Wallman KE. Effects of sodium phosphate and caffeine ingestion on repeated-sprint ability in male athletes. Journal of Science and Medicine in Sport, 2016; 19(3), 272–276, DOI: https://doi.org/10.1016/j.jsams.2015.04.001.
West JS, Ayton T, Wallman KE, Guelfi KJ. The effect of 6 days of sodium phosphate supplementation on appetite, energy intake, and aerobic capacity in trained men and women. International Journal of Sport Nutrition and Exercise Metabolism, 2012; 22(6), 422–429, DOI: https://doi.org/10.1123/ijsnem.22.6.422.
Brewer CP, Dawson B, Wallman KE, Guelfi KJ. Effect of repeated sodium phosphate loading on cycling time-trial performance and VO2peak. International Journal of Sport Nutrition and Exercise Metabolism,2013; 23(2), 187–194, DOI: https://doi.org/10.1123/ijsnem.23.2.187.
Stephens FB, Constantin-Teodosiu D, Greenhaff PL. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. Journal of Physiology, 2007;581(2), 431–444, DOI: https://doi.org/10.1113/jphysiol.2006.125799.
Novakova K, Kummer O, Bouitbir J, Stoffel SD, Hoerler-Koerner U, Bodmer M, ... Krähenbühl S. Effect of L-carnitine supplementation on the body carnitine pool, skeletal muscle energy metabolism and physical performance in male vegetarians. European Journal of Nutrition, 2016; 55(1), 207–217, DOI: https://doi.org/10.1007/s00394-015-0838-9.
Stephens FB, Evans CE, Constantin-Teodosiu D, Greenhaff PL. Carbohydrate ingestion augments L-carnitine retention in humans. Journal of Applied Physiology, 2007; 102(3), 1065–1070, DOI: https://doi.org/10.1152/japplphysiol.01011.2006.
Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. Journal of Physiology, 2011; 589(4), 963–973, DOI: https://doi.org/10.1113/jphysiol.2010.201343.
Peeling P, Binnie MJ, Goods PSR, Sim M, Burke LM. Evidence-based supplements for the enhancement of athletic performance. International Journal of Sport Nutrition and Exercise Metabolism, 2018; 28(2), 178–187, DOI: https://doi.org/10.1123/ijsnem.2017-0343.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Moher D. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. International Journal of Surgery, 2021; 88, 105906, DOI: https://doi.org/10.1016/j.ijsu.2021.105906.
Kuru D, Akitiz S, Atakan MM, Köse MG, Turnagöl HH, Koşar ŞN. Effect of pre-exercise sodium citrate ingestion on repeated sprint performance in soccer players. Journal of Strength and Conditioning Research, 2024; 38(3), 556–562, DOI: https://doi.org/10.1519/JSC.0000000000004651.
Carr AJ, McKay AKA, Burke LM, Smith ES, Urwin CS, Convit L, Jardine WT, Kelly MK, Saunders B. Use of buffers in specific contexts: Highly trained female athletes, extreme environments and combined buffering agents-A narrative review. Sports Medicine,2023; 53(Suppl 1), 25–48, DOI: https://doi.org/10.1007/s40279-023-01872-7.
Płoszczyca K, Gajda R, Czuba M. The effects of sodium phosphate supplementation on the cardiorespiratory system and gross efficiency during exercise under hypoxia in male cyclists: A randomized, placebo-controlled, cross-over study. Nutrients, 2021; 13(10), 3556, DOI: https://doi.org/10.3390/nu13103556.
Pope H, Davis M, Delgado-Charro MB, Peacock OJ, Gonzalez J, Betts JA. Phosphate loading does not improve 30-km cycling time-trial performance in trained cyclists. International Journal of Sport Nutrition and Exercise Metabolism, 2022; 33(2), 93–101, DOI: https://doi.org/10.1123/ijsnem.2022-0111.
López-Torres O, Rodríguez-Longobardo C, Capel-Escoriza R, Fernández-Elías VE. Ergogenic aids to improve physical performance in female athletes: A systematic review with meta-analysis. Nutrients, 2022; 15(1), 81, DOI: https://doi.org/10.3390/nu15010081.
Alhasaniah AH. L-carnitine: Nutrition, pathology, and health benefits. Saudi Journal of Biological Sciences, 2023; 30(2), 103555, DOI: https://doi.org/10.1016/j.sjbs.2022.103555.
Samsudin N, Ahmad NS, Ooi FK, Kadir AA, Kassim NK. Randomised clinical trial of combined L-carnitine supplement and exercise on biochemical markers and exercise performance: A systematic review. Malaysian Journal of Medicine and Health Sciences, 2023; 18(2), 259–270, DOI: https://doi.org/10.47836/mjmhs.19.2.37.
Płoszczyca K, Chalimoniuk M, Przybylska I, Czuba M. (Effects of short-term phosphate loading on aerobic capacity under acute hypoxia in cyclists: A randomized, placebo-controlled, crossover study. Nutrients, 2022; 14(2), 236, DOI: https://doi.org/10.3390/nu14020236.
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